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KMID : 0361020030460050364
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Korean Journal of Otolaryngology - Head and Neck Surgery
2003 Volume.46 No. 5 p.364 ~ p.371
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Three Dimensional Analysis of Caloric, Spontaneous, Positional, Positioning and Post Head Shaking Nystagmus in Bilateral Vestibulotoxic Cats
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여상원/Yeo SW
박시내/김환재/이연수/채세용/이흥엽/오현진/서병도/Park SN/Kim HJ/Lee YS/Chae SY/Lee HY/Oh HJ/Suh BD
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Abstract
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Background and Objectives: Vestibular toxicity can be usually monitored by a caloric test, but measuring eye movements including nystagmus is also helpful in the evaluation of vestibulotoxic process. To understand the vestibular signs during bilateral
vestibulotoxic process, we observed three dimensional serial changes of eye movements and the results of caloric test in cats using a magnetic search coil system.
Materials and Method: Three-dimensional (3-D) eye movement responses to ice water caloric stimulus and spontaneous, positional, positioning, and post head shaking nystagmus in five cats were serially evaluated at 3, 7, 10, 14, 21, 28 days, 2, 3, 4, 5, 6 months after inducing bilateral vesitibulotoxicity by subcutaneous injection of
streptomycin. Histologic changes of vestibular system were also observed.
Results: Bilateral vestibulotixicity which showed no response to ice water caloric stimulus was induced within 2 weeks with streptomycin injection. Positional, positioning and post head shaking nystagmus were present during vestibulotoxic process. Caloric nystagmus did not reappear within 6 months and histologic finding in crista ampullaris of lateral semicircular canal showed marked degeneration of the hair cells and nerves.
Conclusion: Observation of positional, positioning and post head shaking nystagmus as well as ice water caloric test will be helpful to monitor vestibulotoxic process.
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